PicksByJackZak's model predicts Indianapolis Colts 25, San Francisco 49ers 24 for Week 16 2025 (San Francisco 49ers at Indianapolis Colts).
2025 model results, generated with the season's data; not locked pregame. 2025 Week 16 picks · How the picks are made
| Season | 2025 |
| Week | 16 |
| Away | San Francisco 49ers (SF) |
| Home | Indianapolis Colts (IND) |
| Projected score | San Francisco 49ers 24.0 – Indianapolis Colts 24.6 |
| Projected winner | Indianapolis Colts |
| Provenance | 2025 model results, generated with the season's data; not locked pregame. |
This ledger is append-only: nothing in it is ever edited or removed. Predictions from 2026 are written before their game kicks off and carry the UTC timestamp at which they locked. The 2024 and 2025 seasons are archived model results, generated with that season's data and not locked pregame. Scores shown are the model's projected final scores, not results. Machine-readable: JSON · CSV. Player-level projections are withheld until they are verified against the current season's roster feed.